Semax vs Selank
Two Russian-developed nootropic peptides with different primary uses.
Semax (synthetic ACTH 4-10 analogue)
A synthetic heptapeptide approved in Russia for stroke and cognitive disorders, studied for BDNF-driven neuroprotection.
Selank (synthetic tuftsin analogue)
A synthetic anxiolytic peptide developed in Russia, studied for anxiety and mild cognitive effects without sedation.
| Attribute | Semax | Selank |
|---|---|---|
| Category | Nootropic & CNS | Nootropic & CNS |
| FDA status | Not FDA-approved (approved in Russia and Ukraine). PCAC voted to recommend for compounding (July 2026); awaiting FDA rulemaking | Not FDA-approved (approved in Russia) |
| Half-life | Short (minutes); intranasal use | Short (minutes); intranasal use |
| Molecular weight | 813.9 Da | 751.9 Da |
| Mechanism | Increases BDNF and NGF expression and modulates the melanocortin and dopaminergic systems, supporting neuroprotection and synaptic plasticity. | Modulates GABA and monoamine systems and influences enkephalin degradation and BDNF expression, producing anxiolytic effects. |
| Legal status (US) | Not approved; research use only | Not approved; research use only |
Frequently asked questions
What is the difference between Semax and Selank?
Semax: A synthetic heptapeptide approved in Russia for stroke and cognitive disorders, studied for BDNF-driven neuroprotection. Selank: A synthetic anxiolytic peptide developed in Russia, studied for anxiety and mild cognitive effects without sedation.
Which has stronger research evidence, Semax or Selank?
Semax is rated Moderate and Selank is rated Moderate for evidence level in this database. Evidence level reflects the quality of published research, not a recommendation.
Are Semax and Selank FDA-approved?
Semax: Not FDA-approved (approved in Russia and Ukraine). PCAC voted to recommend for compounding (July 2026); awaiting FDA rulemaking. Selank: Not FDA-approved (approved in Russia).
Evidence levels reflect the quality of published research, not a recommendation. This comparison is educational and is not medical advice.