The Longevity Archive
All compounds

Antioxidant

6 evidence-rated antioxidant compounds.

Glutathione

Glutathione (GSH, gamma-glutamyl-cysteinyl-glycine)

Moderate

The body's master intracellular antioxidant tripeptide, used to support redox balance, detoxification, and skin, with mixed clinical evidence for supplementation.

AntioxidantRev. Sep 2026

NAC

N-Acetylcysteine

Strong

A glutathione precursor that is FDA-approved as a mucolytic and antidote for acetaminophen overdose, and studied more broadly in psychiatry and respiratory health.

AntioxidantRev. Sep 2026

Alpha-Lipoic Acid

Alpha-Lipoic Acid (ALA, thioctic acid)

Moderate

A versatile antioxidant compound studied for diabetic nerve pain and metabolic health, sold as a supplement and used as a drug in some countries.

AntioxidantRev. Sep 2026

Ergothioneine

L-Ergothioneine

Preliminary

A diet-derived antioxidant amino acid that accumulates in cells via a dedicated transporter, studied as a possible longevity nutrient.

AntioxidantRev. Sep 2026

Methylene Blue

Methylene blue (methylthioninium chloride)

Preliminary

An FDA-approved antidote for methemoglobinemia that biohackers take at low doses for mitochondrial energy and focus; the cognitive evidence is thin and it is a monoamine oxidase inhibitor with documented fatal interactions with antidepressants.

AntioxidantRev. Sep 2026

SkQ1

SkQ1 (plastoquinonyl decyltriphenylphosphonium, Visomitin)

Preliminary

A mitochondria-targeted antioxidant registered in Russia as an eye drop for dry eye; rodent lifespan claims come from a single research group and oral systemic use has no human data.

AntioxidantRev. Sep 2026