5-Amino-1MQ
5-Amino-1-Methylquinolinium (NNMT inhibitor)
An experimental small-molecule enzyme inhibitor studied in animals for fat metabolism and muscle, popular on longevity resources.
Overview
5-Amino-1MQ is a small molecule that inhibits the enzyme NNMT, which is involved in fat cell metabolism and cellular energy handling. In animal studies, blocking NNMT reduced fat accumulation and supported muscle. Human evidence is absent, so it is preliminary and experimental. It is not a peptide, but it is widely marketed on metabolic and longevity sites.
Mechanism of action
Inhibits nicotinamide N-methyltransferase (NNMT), altering fat cell energy metabolism and preserving cellular NAD-related pathways.
Key studies & citations
- Animal2014
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Identified NNMT as a target: silencing it in adipose tissue and liver protected mice from diet-induced obesity.
Nature - Animal2018
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Small-molecule NNMT inhibitors (the 5-amino-1MQ series) reduced body weight and fat mass in diet-induced obese mice.
Biochemical Pharmacology
Frequently asked questions
Does 5-Amino-1MQ work in humans?
There is no human clinical evidence. The findings are from animal studies, so it is experimental and preliminary.