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The Longevity Archive
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Anti-agingResearch strength: PreliminaryEvidence: Preliminary

Cardiogen

Cardiogen (Ala-Glu-Asp-Arg peptide bioregulator)

A synthetic peptide bioregulator studied in Russian research for cardiovascular tissue and age-related heart changes.

Overview

Cardiogen is a synthetic tetrapeptide categorized as a peptide bioregulator directed at cardiovascular tissue in the Khavinson framework. It is studied for supporting heart muscle and vascular function with age. As with the other bioregulators, evidence comes largely from a single research tradition and is preliminary. It is not approved.

Mechanism of action

Proposed to regulate gene expression in cardiovascular tissue to support heart and vessel function.

Key studies & citations

  • Review2002

    Peptides and ageing

    Khavinson's overview of the peptide bioregulator concept; it does not itself establish efficacy for Cardiogen.

    Neuroendocrinology Letters
  • Review2026

    PubMed search: cardiogen tetrapeptide bioregulator

    (search link; no single primary source identified)

    PubMed search

Frequently asked questions

Does Cardiogen protect the heart?

Evidence is preliminary and comes mainly from one research group. There is no independent clinical proof, so it is best considered experimental.

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