PNC-27
PNC-27, p53-derived membrane-active peptide
An in-vitro cancer-cell-lysing peptide sold online as a cancer cure in nebulized, injectable and other forms; the FDA warned the public after finding bacterial contamination in a product, and no human trial has ever been registered.
Overview
PNC-27 is a p53-derived peptide that binds membrane-bound HDM-2 on cancer cells and punches holes in them in culture. Nothing beyond cell studies exists: no animal efficacy program, no registered clinical trial. Despite that, it is marketed with claims to treat any cancer, and the FDA issued a public warning after a PNC-27 inhalation solution tested positive for Variovorax paradoxus bacteria. It is listed here as a safety alert.
Mechanism of action
Binds HDM-2 expressed on cancer-cell membranes and forms transmembrane pores causing lysis (in vitro).
Key studies & citations
- In vitro2010
PNC-27 induces cancer cell membrane lysis via HDM-2
Cell-culture mechanism.
Cancer Chemotherapy and Pharmacology - Review2019
FDA warning: unapproved cancer 'cure' PNC-27 contaminated with bacteria
Variovorax paradoxus found in a PNC-27 inhalation product.
Pharmacy Times
Frequently asked questions
Does PNC-27 treat cancer?
No trial has tested it in animals or people. It kills cancer cells in a dish; so does bleach. The FDA has warned about contaminated products sold to patients.