Legal status · Australia
Is AICAR legal in Australia?
No. AICAR is not an approved medicine in Australia; its classification is "Not approved; Schedule 4 or import-restricted". Nothing containing it is authorized for any use in people. Vials labeled "for research use only" are not exempt: that label does not make human use lawful. Human evidence: Preliminary.
AICAR in Australia at a glance
| Classification | Not approved; Schedule 4 or import-restricted |
|---|---|
| Note | Prohibited in sport in and out of competition (WADA S4.5) since 2009 |
| TGA approval status | Not approved by TGA |
| Evidence level | Preliminary (research strength: Moderate) |
| Reviewed | Sep 2026 |
Classification and note come from the AICAR profile, checked against Therapeutic Goods Administration (TGA) listings at the reviewed date.
What this means
- 01
No product containing AICAR is approved by TGA for any use in Australia, so nothing on the market is authorized for people.
- 02
"Research use only" is a vendor label, not a legal category that permits human use. It does not exempt a product from medicines law.
- 03
Importing, supplying or promoting it for human use can fall under medicines legislation in Australia. This page is general information, not legal advice.
What AICAR is
The original 'exercise in a pill' from a 2008 Cell paper, an AMPK activator banned by WADA since 2009; human programs in heart surgery and leukemia failed to produce an approved drug, and effective animal doses are impractically large.
AICAR is converted inside cells to ZMP, which mimics AMP and switches on AMPK. In sedentary mice it raised running endurance by about 44%.
Mechanism: Intracellular conversion to ZMP, an AMP analog that activates AMPK and downstream PGC-1alpha and PPARdelta programs.
Regulatory history: Never approved
How TGA treats this kind of product
Registers or lists therapeutic goods on the ARTG and schedules substances in the Poisons Standard. Many peptides are Schedule 4 (prescription only), so possession without a prescription and personal importation are restricted even when no product is registered.
The classification above is the The Longevity Archive reading of Therapeutic Goods Administration listings for AICAR at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
AICAR in other countries
Frequently asked questions
Is AICAR legal in Australia?
No. AICAR is not an approved medicine in Australia; its classification is "Not approved; Schedule 4 or import-restricted". Nothing containing it is authorized for any use in people. Vials labeled "for research use only" are not exempt: that label does not make human use lawful. Human evidence: Preliminary. Note: Prohibited in sport in and out of competition (WADA S4.5) since 2009
Can I buy AICAR in Australia?
No approved product exists to buy. In Australia AICAR is classified as "Not approved; Schedule 4 or import-restricted", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors. Note: Prohibited in sport in and out of competition (WADA S4.5) since 2009
Is AICAR TGA approved?
No. In Australia AICAR is classified as "Not approved; Schedule 4 or import-restricted", which is not a TGA marketing approval. For comparison, the US FDA status is: Never approved. Evidence level: Preliminary.
Related compounds in Australia
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for AICAR live on its compound profile.
AICAR profileThis page is general information about the regulatory status of AICAR in Australia, current as of Sep 2026. It is not legal advice, and classifications change; check Therapeutic Goods Administration directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.