Legal status · United Kingdom
Is PE-22-28 legal in the United Kingdom?
No. PE-22-28 is not an approved medicine in the United Kingdom; its classification is "Not licensed". Nothing containing it is authorized for any use in people. Vials labeled "for research use only" are not exempt: that label does not make human use lawful. Human evidence: Preliminary.
PE-22-28 in the United Kingdom at a glance
| Classification | Not licensed |
|---|---|
| MHRA approval status | Not approved by MHRA |
| Evidence level | Preliminary (research strength: Preliminary) |
| Reviewed | Sep 2026 |
Classification and note come from the PE-22-28 profile, checked against Medicines and Healthcare products Regulatory Agency (MHRA) listings at the reviewed date.
What this means
- 01
No product containing PE-22-28 is approved by MHRA for any use in the United Kingdom, so nothing on the market is authorized for people.
- 02
"Research use only" is a vendor label, not a legal category that permits human use. It does not exempt a product from medicines law.
- 03
Importing, supplying or promoting it for human use can fall under medicines legislation in the United Kingdom. This page is general information, not legal advice.
What PE-22-28 is
An experimental peptide studied for rapid antidepressant effects and neurogenesis by blocking a potassium channel in the brain.
PE-22-28 is a synthetic analogue of spadin that blocks the TREK-1 potassium channel, a target linked to depression. In animal models it produced rapid antidepressant effects and increased neurogenesis, generating interest as a fast-acting antidepressant concept.
Mechanism: Blocks the TREK-1 potassium channel, which is implicated in mood regulation, producing rapid antidepressant-like effects in animals.
Regulatory history: Not FDA-approved; experimental
How MHRA treats this kind of product
Licenses medicines for the UK market. A compound without a marketing authorisation is an unlicensed medicine, which can only lawfully be supplied for human use through a prescriber under the specials scheme, not sold as a research product.
The classification above is the The Longevity Archive reading of Medicines and Healthcare products Regulatory Agency listings for PE-22-28 at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
PE-22-28 in other countries
Frequently asked questions
Is PE-22-28 legal in the United Kingdom?
No. PE-22-28 is not an approved medicine in the United Kingdom; its classification is "Not licensed". Nothing containing it is authorized for any use in people. Vials labeled "for research use only" are not exempt: that label does not make human use lawful. Human evidence: Preliminary.
Can I buy PE-22-28 in the United Kingdom?
No approved product exists to buy. In the United Kingdom PE-22-28 is classified as "Not licensed", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors.
Is PE-22-28 MHRA approved?
No. In the United Kingdom PE-22-28 is classified as "Not licensed", which is not a MHRA marketing approval. For comparison, the US FDA status is: Not FDA-approved; experimental. Evidence level: Preliminary.
Related compounds in the United Kingdom
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for PE-22-28 live on its compound profile.
PE-22-28 profileThis page is general information about the regulatory status of PE-22-28 in the United Kingdom, current as of Sep 2026. It is not legal advice, and classifications change; check Medicines and Healthcare products Regulatory Agency directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.