SLU-PP-332
SLU-PP-332 (ERR agonist exercise mimetic)
An experimental 'exercise mimetic' that activates energy-metabolism pathways in animals, with no human data yet.
Overview
SLU-PP-332 is an experimental compound that activates estrogen-related receptors (ERRs), master regulators of energy metabolism, effectively mimicking some effects of endurance exercise. In rodent studies it increased endurance and improved metabolic measures without exercise. It is early-stage and preclinical, with no human trials, so it is experimental. It is not a peptide.
Mechanism of action
Activates estrogen-related receptors (ERRs) to boost mitochondrial energy metabolism, mimicking endurance exercise adaptations.
Key studies & citations
- Animal2023
Synthetic ERR alpha/beta/gamma agonist induces an ERR alpha-dependent acute aerobic exercise response and enhances exercise capacity
SLU-PP-332 triggered an aerobic-exercise-like transcriptional program in muscle and increased running endurance in mice.
ACS Chemical Biology - Animal2024
A synthetic ERR agonist alleviates metabolic syndrome
In diet-induced obese and ob/ob mice, SLU-PP-332 improved metabolic parameters without exercise.
Journal of Pharmacology and Experimental Therapeutics
Frequently asked questions
Can SLU-PP-332 replace exercise?
No. It mimics some exercise effects in mice, but there is no human evidence, and it remains an experimental compound.