Trodusquemine
Trodusquemine (MSI-1436)
Also known as: MSI-1436
An aminosterol PTP1B inhibitor from dogfish shark that regenerated heart tissue in zebrafish and mice and caused fat-specific weight loss in obese mice; early human trials never produced published efficacy.
Overview
Trodusquemine blocks protein tyrosine phosphatase 1B, a brake on insulin and leptin signaling, and crosses into the brain. Animal studies showed weight loss confined to fat and regeneration of heart and other tissues after injury. Human Phase 1 work in obesity and oncology occurred years ago without published efficacy, and the compound now circulates as a research chemical with no human dosing or safety data.
Mechanism of action
Allosteric, non-competitive PTP1B inhibition enhancing insulin and leptin signaling; regenerative effects via PTP1B-dependent pathways in injured tissue.
Key studies & citations
- Animal2017
MSI-1436 stimulates regeneration of heart and multiple tissues
Cardiac regeneration in zebrafish and post-infarct mice.
NPJ Regenerative Medicine - Animal2010
Trodusquemine causes fat-specific weight loss in diet-induced obese mice
Weight loss confined to adipose tissue.
Obesity
Frequently asked questions
Does trodusquemine regenerate the human heart?
Unknown. The regeneration data are in fish and mice; no human efficacy study has been published.